Engineered natural macrocycle diversity you can screen and scale.
A teaser library of ~1000 natural product-derived macrocyclic peptides, produced in a single defined strain – diverse, new chemical matter, reproducible batch to batch, and scalable by fermentation the moment you find a hit.
No commitment – just tell us what you screen, and we'll keep you posted.
We're assembling a natural-product-based library purpose-built for screening — not a random extract collection, but a designed set with built-in handles for follow-up chemistry.
~1000 compounds, based on natural macrocyclic peptides
Three scaffold types: head-to-tail cyclics, depsipeptides, and linear peptides
5 to 8 amino acids in size
Diversity by design: D-amino acids, non-canonical side-chain variations, halogenated residues, and N-methylated amino acids
Click-ready: azide and alkyne handles built in for downstream click chemistry
Delivered as extracts and/or solid-phase enriched compounds (format specified with you)
Produced in one defined strain. No variable side products.
Traditional natural-product libraries are powerful but messy – irreproducible extracts, inconsistent yields, hits you can't cleanly attribute. Ours come from a single defined production background, so what you screen is what you get, batch to batch. Natural-product chemical space, with reproducibility built in.
A hit you can actually make more of.
Should a hit emerge, scaling for validation is straightforward – we ferment more. No synthetic re-synthesis, no months of route development. And because the library is biologically produced, we can run a fast hit-expansion route: a focused set of new analogs around an early-phase hit, on a timescale synthesis can't match.
Myria is a Basel-based techbio spun out of ETH Zürich, Max Planck, Goethe University, and HIPS.
We reprogram the biosynthetic machinery behind natural macrocyclic peptides to design and produce them on demand.
This first library is a small teaser – a curated set of ~1000 compounds to put real molecules in your hands and see what resonates. It's a window into a much larger accessible space.
Would this be of interest?
We're finalizing the first library now. Tell us a little about what you screen, and we'll be in touch when it's ready.